Fig. 3

Synaptosomes are able to load and release curcumin. a Histogram of the fluorescence intensity and fluorescence image of synaptosomes loaded with Curcumin (Synap-Curcumin). b Schematic representation of LAN5 neuronal cell incubated with Synap-Curcumin. c Histogram of the fluorescence intensity of LAN5 cells incubated with different doses (10–20 µl, which correspond to concentration of 5.1 × 10⁷; 10.2 × 10⁷ particles/100 µl respectively) of Synap-Curcumin for 2 and 4 h. d Representative fluorescence images showing the interaction of Synap-Curcumin with LAN5 cells and control (not treated). Nuclei were stained with Hoechst 33342. *P < 0.05, **P < 0.02 vs Control. Scale bar 20 µm