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Table 2 Vaginal explant histopathological analysis

From: Safety and efficacy of G2-S16 dendrimer as microbicide in healthy human vaginal tissue explants

 

NT 1

G2-S16 (3 mM)

N9 (4.5%)

Epithelial injury

1

1

2

2

0

2

2

2

1

2

2

0

2

1

1

2

1

2

4

4

3

4

4

Glandular cystic dilation

1

0

0

0

0

1

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

Inflammatory infiltrate

0

1

0

0

1

1

0

0

1

1

0

2

1

0

0

0

0

1

0

2

0

0

0

Hemorrhage

1

0

0

0

1

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

Vascular proliferation

0

2

2

0

0

1

2

2

1

1

2

1

1

0

2

1

1

0

3

4

4

3

4

Edema/fibrosis

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

Necrosis

1

2

1

0

0

1

0

2

0

1

2

1

1

1

2

1

0

1

3

4

3

3

4

Calcifications

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

Total score

4

6

5

2

2

6

4

6

3

5

6

4

6

1

5

4

2

4

10

14

10

10

12

  1. Injury existence was evaluated in each ETP sample for epithelial injury, glandular cystic dilation, inflammatory infiltrate, hemorrhage, vascular proliferation, edema or fibrosis, necrosis and calcifications
  2. 1 0 (no change); 1 (minimum); 2 (light); 3 (moderate); 4 (very serious). Total score summatory set the histopathological analysis score as minimum 1–6, average 7–10, moderate 10–14, and severe 14 + .
  3. N9 nonoxynol-9
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Journal of Nanobiotechnology

ISSN: 1477-3155

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