Fig. 10

Surface charge-dependent circulation of NMs. A schematic representation of photoswitching of the surface charge of a liposome. B real time multi-photon imaging of liposome distribution with or without UV exposure. At later times, large aggregations of liposomes (white arrows) were detected passing through the plane of view in circulation. c mean fluorescence intensity within the lumen of dorsal aorta (white square, − UV and + UV 15 min). Fluorescence intensity of liposomes immediately reduced upon UV exposure. Large circulating aggregates of liposomes caused high intensity spikes of fluorescence registered after 5 min of UV irradiation. Reproduced with permission from [211]. Copyright 2020, Springer Nature