Fig.4
From: Ultrasound-assisted brain delivery of nanomedicines for brain tumor therapy: advance and prospect
![Fig.4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12951-022-01464-z/MediaObjects/12951_2022_1464_Fig4_HTML.png)
A FUS combined with PFCNDs induced BBB opening with acoustic pressure of 0.5 MPa, 1.0 MPa and 1.5 MPa. a–c EB staining of brain; d–g enlarged (× 40) corresponding black rectangle region in H&E stain; g–i enlarged (× 200) corresponding black rectangle region in H&E stain. B Distribution pattern of EB extravasation when nanodroplets or MBs was used as mediating agent combined with FUS [45]