Fig. 4
From: Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy
![Fig. 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12951-022-01548-w/MediaObjects/12951_2022_1548_Fig4_HTML.png)
Thrombosis in the tumor triggers enhanced hypoxia-activated prodrug therapy. a Schematic fabrication of Th-TPZ@MOF-FA and the mechanism of degradation and prodrug activation. b Schematic illustration of the formation of thrombosis in the tumor and enhanced hypoxia-activated prodrug therapy. c Blood clot formation in vitro and thrombosis in tumors treated with  intravenous injection of Th-TPZ@MOF-FA. d CD 41-stained tumor sections at different time points after the administration of Th-TPZ@MOF-FA. e The in vivo antitumor activity of Th-TPZ@MOF-FA [32]. Copyright©2021 Wiley-VCH GmbH