From: Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
Nanozyme material | Disease | Type of functions | Signaling mechanism | Therapeutic effects | Reference |
---|---|---|---|---|---|
Pd@PEG@Bor | AD | SOD, CAT | ROS↓; inhibit Aβ plaque deposition | Alleviate neuron loss, and neuroinflammation; improve cognitive impairment | [121] |
Fe-Nx SANs | AD | POD | Enhance the detection performance of Aβ 1-40 | Ultrasensitive colorimetric immunoassay | [132] |
PEG-Fe3O4 | AD | SOD, CAT | ROS↓; PECAM-1↑; claudin5↑; ZO-1↑ | Improve neuroblast differentiation in the hippocampal dentate gyrus | [133] |
KLVFF@Au-CeO2 | AD | SOD, CAT | ROS↓; inhibit Aβ | Aggregation and degrade Aβ fibril; improve the cognitive function | [134] |
TPP-MoS2 QDs | AD | SOD, CAT | ROS↓; IL-1β↓; IL-6↓; TNF-α↓; TGF-β↑ | Degrade Aβ deposits; attenuate inflammatory | [135] |
KD8@N-MCNs | AD | SOD, CAT | ROS↓; IL-1β↓; TNF-α↓ | Decrease Aβ deposits, ameliorate memory deficits, and alleviate neuroinflammation | [136] |
2D V2C MXenzyme | PD | SOD, CAT, GPx | ROS↓; tyrosine hydroxylase↑; IBA-1↓ | Inhibit inflammation | [137] |
Lf-Au-Bi2Se3 | PD | SOD, CAT, GPx | ROS↓ | Improve the memory and mobility, protect mitochondria, suppress dopaminergic neuron loss in the substantia nigra pars compacta | [138] |
Mnf | PD | SOD, CAT, GPx | ROS↓ | Inhibit caspases-3/7 activation | [139] |
PBzyme | PD | SOD, CAT | ROS↓; NLRP3 inflammasomes↓; caspase-1↓; GSDMD↓ | Reduces dopaminergic degeneration and inhibits neuroinflammation; alleviates motor deficits, attenuates the damage of mitochondrial membrane potential, and rescues dopaminergic neurons | [140] |
Fe2NC@Se | Stroke | SOD, CAT, GPx | ROS↓ | Improve neurological function, decrease brain infarct volumes and edema, ameliorate brain injury; inhibit ASK1/JNK pathway | [141] |
PNzyme/MnO2 | Stroke | SOD, CAT | ROS↓; TNF-α↓; IL-6↓ | Inhibit inflammation; reduces cerebral infarction; improve neurological function | [25] |
Pt/CeO2 | Brain injury | SOD, CAT, GPx | ROS↓; RNS↓ | Improve the wound healing of neurotrauma and reduce neuroinflammation | [142] |
PtPdMo triM | Brain injury | SOD, CAT | ROS↓; RNS↓ | Suppress neuroinflammation; attenuate brain injury and improve memory | [60] |
Cr/CeO2 | Brain injury | SOD, CAT, GPx | ROS↓; RNS↓; MMP-9↓ | Improve the wound healing and reduce neuroinflammation; improve neuronal cognition | [143] |