Fig. 6

miR-100-5p attenuation arthritis of CIA mice. (A) Arthritis score in two groups. (B) mRNA expression of TNF-α, IL-1β, IL-6, IL-8, MMP-1, and MMP-13 in ankle joint of three groups. (C) Levels of TNF-α, IL-1β, IL-6, and IL-8 in serum of three groups. (D) H&E staining of knee and ankle joints of CIA and normal control mice. Data are presented as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001