The effects of exosomes originating from different cell sources on the differentiation of bone marrow mesenchymal stem cells into schwann cells

Table 3 Enrichment results of the same differential gene among different groups

		NSC vs. Fb/RSC vs. Fb	RSC vs. Fb/RSC vs. NSC	NSC vs. Fb/RSC vs. NSC
GO Enrichment of Genes	Biological Process	None	Cell death Negative regulation of biological process Negative regulation of cellular process	None
	Cellular component	Cytoplasmic part Cytoplasm Catalytic complex Mitochondrial part	Cytoplasmic part Cytoplasm Intracellular vesicle Cytoplasmic vesicle Vesicle Extracellular region Extracellular region part	Cytoplasmic part Cytoplasm Membrane-bounded organelle Intracellular Intracellular part Membrane-bound organelle
	Molecular Function	Protein dimerization activity Protein binding Identical protein binding Ubiquitin conjugating Enzyme activity	Protein dimerization activity Protein binding Identical protein binding Protein homodimerization activity	Protein dimerization activity Protein binding Identical protein binding Catalytic activity Molecular function regulator Chemokine activity binding
Intersection of differential gene enrichment analyses in KEGG and GSEA		Spliceosome, Oocyte meiosis, Cell cycle, Carbon metabolism, Glycine, serine and threonine metabolism, DNA replication, Cysteine and methionine metabolism, Dopaminergic synapse, Proteasome, Pyruvate metabolism, RNA polymerase, mRNA surveillance pathway, SNARE interactions in vesicular transport

Regardless of whether gene expression was up- or down-regulated, we identified groups showing statistical significance (P ≤ 0.05); for our analysis, we created three paired groups: NSC vs. Fb, RSC vs. Fb and NSC vs. RSC. The italized sections represent three groups of identically expressed genes

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