Fig. 4

Biodistribution of Hm@TSA/As-MOF. The distribution of free DiD, DiD-MOF, Hm@DiD-MOF and Hm@DiD-MOF plus magnet in mice with HCC was visualised using an IVIS Spectrum imaging system (A). After 24 h, ex vivo imaging of various organs (B) and tumour tissues (C) was performed using an IVIS Spectrum imaging system. Subsequently, the ex vivo images of tumour tissues were analysed (D) (n = 3). The distribution of free DiD, DiD-MOF, Hm@DiD-MOF and Hm@DiD-MOF plus magnet in tumour tissues was examined via confocal laser microscopy (scale bar = 200 μm) (E) (I, DiD; II, DiD-MOF; III, Hm@DiD-MOF; IV, Hm@DiD-MOF plus magnet). Data are expressed as the mean ± SD (***, p < 0.001; two-tailed Student’s t-test)