Fig. 5
MVMαCD3chDC exerted therapeutic effects in CLP-induced sepsis models. A Timeline of MVMαCD3chDC treatment experiment in sepsis model. B Ventral view of mice from different treatment groups. C-D Percentage of CD3+CD4+FoxP3+ Treg in CD3+CD4+ T cells in spleen and lymph nodes in sepsis mice after different treatments using flow cytometry analysis. E-F H&E staining images of liver and kidney tissues after different treatments. Scale bar = 100 μm. Black and red arrows indicated invasion of inflammation. G The concentrations of TNF-α, IL-6, and IL-10 in the serum of mice after different treatments. H Survival curves of mice after different treatments. Mice with CLP-induced sepsis model continued to treatment every 24 h for 7 days instead of euthanizing at 24 h time point. Data were presented as mean ± SD. Statistical analyses were performed by One-way ANOVA with Tukey method. N = 6 per group. ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 compared with the MVMαCD3chDC group. Statistical analyses in survival curves were performed by Log-rank tests, N = 8 per group. ns P > 0.05, *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the PBS group