Fig. 7

Theoretical evaluation of MOF-based single-atom catalysts for periodontitis treatment. A Schematic of MOF-based single-atom catalysis systems and a porphyrin metal–organic framework (PCN-222-Pt). B PCN-222-Pt, which generates ROS spontaneously and exhibits potent OXD-like and POD-like activities, demonstrates exceptional anti-biofilm efficacy (98.69% against S. aureus biofilm, 99.91% against E. coli biofilm) in vitro within one hour [134]