Table 2 Potential utilizing of nanozymes in dental implant

CuN4-CNS

The findings obtained from both in vitro and in vivo experiments indicate that the ideal CuN4-CNS has great therapeutic effectiveness in treating both deep implant-related biofilm infections and superficial skin wounds by successfully inhibiting multidrug-resistant bacteria and eliminating recalcitrant biofilms

[68]

Fe-NC@TNT

Fe-NC@TNT was examined for its physical composition, surface morphology, enzyme-like catalytic activity, inflammatory response, and compatibility with soft tissues.Fe-NC@TNT has also been shown in vivo animal trials to successfully control the immune response and facilitate the integration of the implant with the surrounding soft tissues

[114]

TNT-ZIF-67@OGP

The TNT-ZIF-67@OGP demonstrated potent antibacterial efficacy against S. aureus, MRSA, E. coli, and S. mutans due to ZIF-67 NP hydrolysis and the creation of an alkaline microenvironment

[115]

BIONPs

Reports a new "interference-regulation strategy" for fighting BAIs that uses bovine serum albumin-iridium oxide NPs (BIONPs) as an immunomodulator and biofilm homeostasis interrupter via singlet oxygen (¹O₂)-sensitized mild hyperthermia

[116]

Cu₂MoS₄

pH-responsive enzyme-like activities were used to construct multifunctional smart hollow Cu₂MoS₄ nanospheres (H-CMS NSs) that can self-adapt to eliminate biofilms and control macrophage inflammation in implant infections

[117]

Cu-CDs/H₂O₂

Antibacterial properties against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, preventing wound purulent infection and accelerating wound healing. In addition, the Cu-CDs/H₂O₂ system exhibits superior tooth whitening performance compared to other alternatives, such as clinically utilized H₂O₂ and CDs, due to its negligible enamel and dentin degradation

[118]