Table 3 Antibacterial effects of several nanozymes in peri-implantitis
Nanozymes | Antibacterial mechanism and function | Reference |
|---|---|---|
Manganese Oxide Nanozyme-Doped Diatom | The method entails decontaminating biofilms adhered to implants by utilizing the kinetic energy of microsized oxygen bubbles produced by a catalytic reaction involving manganese oxide (MnO2) nanozyme sheet-doped silica diatom microparticles (Diatom Microbubbler, DM) | [126] |
TA-Ce-Mino | A mussel-bioinspired implant abutment coating containing tannic acid (TA), cerium, and minocycline (TA-Ce-Mino) is reported. TA provides pyrogallol and catechol groups to promote cell adherence. Besides, Ce3+/Ce4+ conversion exhibits enzyme-mimetic activity to remove reactive oxygen species while generating O2 | [129] |
CDT | A novel non-antibiotic strategy based on the synergy of bionanocatalysts-driven heat-amplified chemodynamic therapy (CDT) and innate immunomodulation is proposed for specific biofilm elimination by the smart design of a biofilm microenvironment (BME)-responsive double-layered metal–organic framework (MOF) bionanocatalysts (MACG) composed of MIL-100 and CuBTC | [127] |
Au-TNT | Ultrasound-activated antibacterial sonodynamic therapy (aSDT) has gained recognition in recent times as a promising approach to the treatment of biofilm infections. For aSDT, an activatable nanoplatform (Au-TNT) fabricated on the implant's surface is proposed in this investigation. Under ultrasonic irradiation, Au-TNT could swiftly generate O2, thereby alleviating the hypoxic microenvironment of biofilm and enhancing the anti-biofilm efficacy of aSDT | [128] |
A MnO2 nanozyme-doped diatom microbubbler (DM) | For the eradication of biofilm, a MnO2 nanozyme-doped DM was recently developed. By simulating the activity of CAT in H2O2 solution, DM can produce oxygen and moving with the ejection of oxygen microbubbles, thereby producing a mechanical self-cleaning effect | [130] |