Table 4 Antibacterial effect of different nanozymes in periodontitis

CeO₂

Experiments in vivo and in vitro provide substantial evidence that CeO₂ NPs scavenge multiple ROS and inhibit lipopolysaccharide-stimulated ROS-induced inflammatory responses. As a result, CeO₂ NPs with high CAT-like and SOD-like activity, in addition to ˙OH scavenging capability, were synthesized

[65]

PCN-222-Pt

PCN-222-Pt, which generates ROS spontaneously and exhibits potent OXD-like and POD-like activities, demonstrates exceptional anti-biofilm efficacy (98.69% against S. aureus biofilm, 99.91% against E. coli biofilm) in vitro within one hour. In contrast to the clinically prescribed periocline, the injectable PCN-222-Pt ointment demonstrated a reduced bone degradation rate, healthier periodontal tissue, and an alleviation of inflammation response in treating biofilm-induced periodontitis

[134]

Au/Pt NCs@GOX

Evidence was obtained from in vivo animal experiments demonstrating that the Au/Pt NCs@GOX clusterzyme effectively and safely treated periodontitis in rats, inhibited inflammation, and stimulated periodontal tissue regeneration

[38]

TM/BHT/CuTA

The TM/BHT/CuTA hydrogel system, which is composed of Cu-based nanozymes (Cu tannic acid coordination nanosheets, CuTA NSs) and triglycerol monostearate/2,6-di-tert-butyl-4-methylphenol (TM/BHT) hydrogel, has been proposed by researchers

[135]

MIL-47(V)-F (MVF)

By employing the MIL-47(V)-F (MVF) nanozyme, which emulates the activity of glutathione POD (GPx), this research suggests that ROS can be effectively regulated through the targeted elimination of H₂O₂, the most abundant ROS. MVF promotes periodontal regeneration, controls inflammation, and regulates the immune microenvironment using H₂O₂ elimination

[136]

FeSN

A separate investigation devised a novel FeSN, which was produced by doping histidine-doped FeS2 and exhibited significant POD-like activity to eliminate oral biofilm and manage periodontitis

[30]

Au/Pt NCs@GOX

Animal experiments in vivo demonstrated that the Au/Pt NCs@GOX clusterzyme could effectively treat periodontitis in rodents, reduce inflammation, and stimulate the regeneration of periodontal tissue while remaining safe to use

[38]